Summary :
The Bio2 projects encompasses modeling and experimental interdisciplinary activities. Both Japan and French teams are involved in the Geant4-DNA project aiming at extending the Geant4 Monte Carlo toolkit for the modeling of early biological effects of ionising radiation at the DNA scale. In 2014, the physics models of Geant4-DNA have all been deployed to GPGPU allowing to reach impressive performance (> 200 speed gain). This porting allowed in particular a deep testing of Geant4-DNA physics models. In 2015 and 2016, the porting of new Geant4-DNA physics models as well as physico-chemistry and chemistry processes has been achieved for the first time reaching again impressive computing performance; this will significantly boost the development of Geant4-DNA based applications at the physics-biology frontier.

French members :
S. Incerti, D. Sakata

Japanese members :
T. Sasaki, K. Amako, Y. Hirano, A. Kimura, K. Murakami, S. Okado, C. Omachi, T. Toshito

References :
[1] The Geant4-DNA project, S. Incerti, G. Baldacchino, M. Bernal, R. Capra, C. Champion, Z. Francis, S. Guatelli, P. Guèye, A. Mantero, B. Mascialino, P. Moretto, P. Nieminen, A. Rosenfeld, C. Villagrasa and C. Zacharatou, Int. J. Model. Simul. Sci. Comput. 1 (2010) 157–178

[2] Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation, H. N. Tran, M. Karamitros, V. Ivantchenko, S. Guatelli, S. McKinnon, K. Murakami, T. Sasaki, S. Okada, M.C. Bordage, Z. Francis, Z. EL Bitar, M. A. Bernal, J. I. Shin, S. B. Lee, Ph. Barberet, T.T. Tran, J. M. C. Brown, S. Incerti, Nucl. Instrum. Meth. B 373 (2016) 126-139

[3] GPU Acceleration of Monte Carlo Simulation at the Cellular and DNA Levels, S. Okada, K. Murakami, K. Amako, T. Sasaki, S. Incerti, M. Karamitros, N. Henderson, M. Gerritsen, M. Asai, A. Dotti, Smart Innovation, Systems and Technologies 45 (2016) 323-332

[4] Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit, M. A. Bernal, M. C. Bordage, J. M. C. Brown, M. Davídková, E. Delage, Z. El Bitar, S. A. Enger, Z. Francis, S. Guatelli, V. N. Ivanchenko, M. Karamitros, I. Kyriakou, L. Maigne, S. Meylan, K. Murakami, S. Okada, H. Payno, Y. Perrot, I. Petrovic, Q.T. Pham, A. Ristic-Fira, T. Sasaki, V. Štěpán, H. N. Tran, C. Villagrasa, S. Incerti, Phys. Med. 31 (2015) 861-874

Website :
http://geant4-dna.org

Summary :
The IPNL-RIKEN/TMU project aims to investigate by two complementary technics the fragmentation and the lifetime of excited states of biologically relevant molecules. The experimental method developed at RIKEN (Japan) uses the RICE-ring, Riken Cryogenic Electrostatic ring, and that developed at the IPNL (Lyon) uses the DIAM, Device for molecular cluster irradiation. The experiments undertaken in both laboratories will provide complementary information and a better understanding of the physical chemistry of biomolecular ions such as nucleobases or proteins.

French members :
M. Farizon, H. Abdoul-Carime, B. Farizon, L. Feketeova

Japanese members :
T. Azuma, T. Furukawa, S. Kuma, J. Matsumoto, Y. Nakano, H. Shiromaru, H. Tanuma

References :
[1] Y. Nakano, W. Morimoto, T. Majima, J. Matsumoto, H. Tanuma, H. Shiromaru, and T. Azuma. A cryogenic electrostatic storage ring project at Riken. Journal of Physics:Conference Series 388:142027, 2012
[2] G. Bruny, S. Eden, S. Feil, R. Fillol, K. El Farkh, M. Harb, C. Teyssier, Ouaskit S., Abdoul-Carime H., B. Farizon B., M. Farizon, T.D. Märk. A new experimental setup designed for the investigation of irradiation of nanosystems in the gas phase: A high intensity mass and energy selected cluster beam. Review of Scientific Instruments, 83:013305, 2012

Website :
http://www.riken.jp/en/research/labs/chief/atom_mol_opt_phys/
https://www.ipnl.in2p3.fr/spip.php?rubrique62